Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis
نویسندگان
چکیده
منابع مشابه
Soluble ST2 suppresses the effect of interleukin-33 on lung type 2 innate lymphoid cells
Type 2 innate lymphoid cells (ILC2) in lungs produce interleukin (IL)-5 and IL-13 in response to IL-33 and may contribute to the development of allergic diseases such as asthma. However, little is known about negative regulators and effective inhibitors controlling ILC2 function. Here, we show that soluble ST2, a member of the IL-1 receptor family, suppresses the effect of IL-33 on lung ILC2 in...
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Innate immunity provides the first line of response to invading pathogens and a variety of environmental insults. Recent studies identified novel subsets of innate lymphoid cells that are capable of mediating immune responses in mucosal organs. In this paper, we describe a subset of lymphoid cells that is involved in innate type 2 immunity in the lungs. Airway exposure of naive BALB/c or C57BL/...
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Purpose of review: The purpose of this article is to review recent advances in our understanding of innate lymphoid cell function and to speculate on how these cells may become activated and influence the immune response to allogeneic tissues and cells following transplantation. Recent findings: Innate lymphoid cells encompass several novel cell types whose wide ranging roles in the immune syst...
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Innate lymphoid cells (ILCs) are lymphoid cells that do not express rearranged receptors and have important effector and regulatory functions in innate immunity and tissue remodeling. ILCs are categorized into 3 groups based on their distinct patterns of cytokine production and the requirement of particular transcription factors for their development and function. Group 1 ILCs (ILC1s) produce i...
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ژورنال
عنوان ژورنال: Immunity
سال: 2013
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2013.07.018